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DMF MSE 2 2011

1

Which one of the following statements best describes the role of C3b?


2

Which one of the following statements best describes a feature shared between cells of the innate and adaptive immune systems?


3

Which one of the statements below best describes the features of Class I MHC antigens?


4

A mature dendritic cell that expresses co-stimulatory molecules and secretes IL-12 presents an antigen to a CD4 T cell that has a TCR able to bind the MHC Class II-peptide complex. Which one of the statements below best describes the likely outcome of this encounter?


5

James Johnstone is an 18 month old boy who has been diagnosed with pneumonia due to Pneumocystis jiroveci infection.
Further investigations show that he has normal numbers of circulating leucocytes, including T and B cells.
He has normal levels of complement, however his plasma contains abnormally high levels of IgM and only trace levels of IgG and IgA for his age.
He is blood group “O” and has been vaccinated with triple-antigen vaccine.
Further tests of his immune function were undertaken. Which one of the following statements correctly describes a result you would expect from these tests?


6

Three children from the same family have been referred to the Immunology Department in a Children’s Hospital because they have all had multiple serious virus infections for most of their lives. Analysis of their leucocytes shows that they have normal numbers of all types, including neutrophils, monocytes, NK cells, B cells, CD8 and CD4 T cells. The levels of complement and antibodies in the patients’ blood were all normal. Which one of the following would best explain the patients’problem?


7

Which one of the following antibody isotypes is correctly paired with its function?


8

Select the correct statement about the events that take place during maturation of T cells in the thymus:


9

A 2-year old boy is seen by a paediatrician because of his failure to thrive and recurrent bouts of diarrhoea and stomach discomfort. After negative investigations for infectious causes, a jejunal biopsy was performed - this revealed villous atrophy, with hyperplasia of the crypts and excess intestinal mononuclear cells.
Which one of the following would be a likely clinical finding in this patient?


10

In many autoimmune diseases there is a predominant form of immune response associated with tissue damage. Which one of the following statements best describes this association?


11

The effectiveness of glucocorticoids as anti-allergy drugs is best explained by which one of the following options?


12

Which one of the following statements regarding vaccines is correct?


13

A 5 year old girl was taken to her GP with headache and fever. She had mild photophobia and neck stiffness. She had previously been well and had received all of her immunisations. The GP administered intramuscular benzyl penicillin, and the girl was sent to the emergency room of a nearby teaching hospital.
CSF obtained via lumbar puncture on her arrival at hospital contained 260 lymphocytes/цl, 35 polymorphonuclear leukocytes/цl, and 0.5 g protein per litre (normal < 0.4 g/l); glucose was normal.
Which one of the infectious agents listed below is the most likely cause of her condition?


14

Which one of the following statements about viruses is correct?


15

Which one of the following statements regarding inflammatory cells is INCORRECT?