DMF Week 4 SAQ

1

Which one of the following statements regarding the complement cascade is incorrect?


2

Which of the following is NOT common to the lectin and alternative pathway of complement activation


3

Pattern recognition receptors (PRR) are important recognition molecules of the innate immune system. Which one of the following statements best describes their function?


4

Which one of the following statements is correct?


5

Which one of the statements about B cell interaction with their antigen is incorrect?


6

Which one of the following is correct regarding the structure of MHC molecules?


7

Which one or more of the following statements about T cell function is correct?

A: T cells which express CD4 can interact with HLA A, B and C antigens.

B: Helper T cells interact with MHC Class II - peptide complexes displayed by antigen activated B cells in secondary lymphoid tissues, resulting in isotype switching

C: T cells which express CD4 can bind free antigens in infected tissues, and help phagocytes to remove them.

D: Cytotoxic T cells recognise viral peptides held in Class I MHC molecules on infected tissue cells.


8

Which one or more of the following statements is correct regarding T cell receptors?

A: T cell activation can only proceed in vivo when the V and J domains of the alpha chain and V, D and J domains of the beta chain of a T cell receptor interacts with peptides held in the cleft of an MHC molecule.

B: Most thymic T cells die, either because they fail to bind self MHC-peptide complexes displayed on cells in the thymus, or because they bind the complexes with too high an affinity.

C: Somatic mutation and somatic gene rearrangements resulting in combinatorial and junctional diversity contribute to the generation of diversity of both B and T cell receptors.

D: T cells which exit the thymus express either CD4 or CD8 co-receptors, and bind self MHC-peptide complexes with low affinity.


9

Which one of the following statements about T cell activation is correct?


10

Which one of the following statements regarding immunodeficiencies is incorrect?