Quisitor - Take Quiz

1

Which one of the following human hormones is not a glyco-protein consisting of both alpha- and beta- subunits?

Follicle-stimulating hormone (FSH).

Luteinizing hormone (LH).

Thyroid stimulating hormone (TSH).

Prolactin (PRL).

Chorionic gonadotrophin (HCG).

2

Which one of the following statements about the effect of hypothalamic hormones on pituitary hormone secretion is not correct?

GnRH pulses result in the release of pulses of FSH and LH by the pituitary.

CRF results in the release of ACTH by the pituitary.

Dopamine inhibits the release of prolactin by the pituitary.

TRH releases the pituitary from secreting TSH.

GHRH results in the release of GH by the pituitary.

3

A 23 year-old pregnant woman is involved in a motor vehicle accident and sustains a fracture of the base of the skull, which has resulted in the pituitary stalk being divided. No other damage has been sustained and the hypothalamic-hypophyseal blood vessels are not affected. Which one of the following is most likely?

She will be shown to have no growth hormone response to insulin induced hypoglycaemia.

Her plasma cortisol level will be low.

Her prolactin level will be increased to levels higher than those normally seen in pregnancy.

She will not labour unless given an infusion of oxytocin.

She will be thirsty and her urine output will be in excess of 5 litres per day.

4

Which one of the following events is not stimulated by TSH?

Coupling of two di-iodotyrosines (DITs) to form thyroxine.

Iodide uptake by the thyroid via an active transport process.

Activity of the deiodinase enzymes.

Binding of triiodothyronine to its receptor.

Growth of the thyroid follicle cell.

5

Iodine deficiency has been shown to be associated with all of the following effects, except

Goitre

Hypothyroidism

Fetal congenital abnormalities

Mental retardation.

Exophthalmos.

6

When measuring the level of a particular hormone in the blood using an immunoassay, all of the following are usually required except

Known amounts of the hormone to be measured to set up a “standard curve”.

Minute amounts of a purified form of the hormone appropriately “labelled” with a radio- isotope or other label.

Antibody to that hormone.

A detection method to measure the total amount of “label”.

A blood sample with an unknown amount of the hormone to be measured.

7

Six weeks after thyroid surgery a patient is noticed to have a hoarse voice. Damage to which one of the following nerves at the time of the surgery is most likely to be the cause of this symptom?

The superior laryngeal nerve

The internal laryngeal nerve

The external laryngeal nerve

The recurrent laryngeal nerve

The vagus nerve

8

A 2-year old boy presents with early pubic hair development, an enlarged penis, tall stature and over- developed muscles for his age. His testes are of normal size for a boy of two. His older sister was born with ambiguous genitalia. Which one of the following statements about this boy is correct?

He has central (true) precocious puberty

An androgen-secreting adrenal tumour is likely in this case

He has the severe salt-wasting form of 21-hydroxylase deficiency

He should be treated with hydrocortisone for life.

His bone age will be delayed.

9

Which one of the following statements about the hormone adrenaline is correct?

It acts on cytosolic receptors to increase gene expression.

It acts on nuclear receptors to decrease gene expression.

It acts on cell surface receptors that have intrinsic tyrosine kinase activity.

It acts on cell surface receptors that couple to G proteins.

It acts on a cell surface receptor with intrinsic guanylate cyclase activity.

10

Which one of the following is not a site of testosterone production?

the ovary

the fetal testis

the adrenal medulla

the ageing testis

the neonate

CSGD Quiz 4 2004

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