DMF MSE 2 2007

1

Which one of the following statements about antibody gene rearrangement is correct?


2

Which one of the following statements about HLA molecules is correct?


3

The activation of T and B cells is the central process of the adaptive immune system. Which one of the statements below correctly describes features in the activation process which are shared by both T and B cells?


4

Which one of the statements below concerning antigen presenting cells is correct?


5

CD8 Cytotoxic T cells and Natural Killer (NK) cells possess several shared characteristics. Select the characteristic described below which is not shared by both cell types


6

Which one of the following statements about the pathogenesis of diseases caused by immune responses is incorrect?


7

Which one of the following statements below is regarding clonal anergy?


8

Which one of the following statements about immediate (Type I) hypersensitivity reactions is correct?


9

Which one of the following statements about mast cells is incorrect?


10

Which one of the following statements about vaccines is correct?


11

Tania Plotkin, a sixteen year old girl, was investigated for an immune deficiency because of a history of recurrent infections.

On investigation, her levels of immunoglobulins and complement components were normal. Assays for antibodies to vaccine antigens showed normal levels of antibodies to these antigens. Her neutrophil numbers and function were also normal.

Tania’s T cell numbers, as determined by measuring the number of cells expressing CD3, were found to be normal. B cell numbers were also normal and they expressed MHC Class II antigens. However, Tania’s lymphocytes and other nucleated cells did not express MHC Class I antigens.

Which one of the following would be consistent with these laboratory data?


12

Which one of the following statements concerning increased vascular permeability associated with acute inflammation is incorrect?


13

Which one of the following statements concerning cells associated with acute inflammation is incorrect?


14

One of the currently licensed vaccines against Streptococcus pneumoniae which is designed to induce protection against invasive pneumococcal disease is prepared from chemical conjugates of pneumococcal surface polysaccharides and a protein such as tetanus toxoid. Which one of the statements below correctly describes the features of this vaccine?


15

A 17 year old girl presented to the emergency department of a teaching hospital with a one day history of headache, fever and photophobia. She had previously been well and had received all of her immunisations. CSF and blood cultures were collected and IV cefotaxime was administered. 45 minutes later the laboratory reported the following CSF results: 1140 leucocytes/μl (90% polymorphonuclear leukocytes); protein 2.0g per litre (normal < 0.4g/l); glucose 1.7mmol/l (normal ≥ 2.5 mmol/l); Gram negative diplococci seen on Gram stain; Latex agglutination tests for H. influenzae type b and Neisseria meningitidis were negative. On the basis of the test results, which one of the following infectious agents listed below is the most likely cause of her condition?


16

When confronted with an angry patient, which one of the following is least likely to be correct?


17

When managing a tearful patient which statement is least likely to be correct?


18

When faced with a distressed family member, which statement is least likely to be correct?


19

Which one of the following changes will result in a significant fall in prevalence of gonorrhoea in a population with a high rate of gonorrhoea among heterosexuals?


20

Which one of the following is least effective in reducing the prevalence of STIs (sexually transmissible infections)?


21

The number of secondary infections that arise from one infectious case of a particular disease may be increased by which one of the following factors?


22

Which one of the following factors favours the eradication of an infectious disease of humans?