HP4 Lecture 8
Which of the following is NOT a generally recognised cause of memory impairment?
Temporal lobe epilepsy
Bilateral thalamic infarction
E is correct: Statins such as Lipitor were a subject of controversy regarding sudden-onset memory impairment, but subsequent studies have shown them to be safe.
Which of the following statements about memory systems is INCORRECT?
The declarative and procedural systems can become impaired independently
Skill acquisition is part of procedural memory
Working memory is important in executive function
Episodic memory is heavily dependent on temporal, spatial and emotional context
Damage to the prefrontal cortex will most likely affect procedural memory
Damage to the prefrontal and dorsolateral cortices is associated with working memory deficiencies.
Which of the following statements about lesion-associated memory impairment is CORRECT?
Retrograde amnesia refers to the inability to recall events that happened after an amnesia-inducing injury
Episodic memory impairment is often associated with lesions to neocortical areas of the brain
Amnesia is often observed following unilateral hippocampal resection
Patient HM's anterograde amnesia was responsible for his inability to recognise people he had recently met
The enterorhinal cortex is not associated with amnesia-inducing lesions
A is incorrect: This is anterograde amnesia B is incorrect: Episodic memory structures are 'all' midline structures, not neocortical C is incorrect: Unilateral hippocampal resection is a viable epilepsy treatment and often does not significantly affect memory D is correct: See A E is incorrect: The enterorhinal cortex is a major hub in the memory network of the brain (it was one of the structures removed in patient HM)
Mild cognitive impairment (MCI) does not typically result in:
Complaints of problems with object-place associations
Reduced ability to cope with everyday activities
Objective memory impairment
A subsequent transition to dementia
MCI differs from dementia in that general cognitive and functional abilites are preserved.
Alzheimer's disease (AD) is the commonest cause of dementia. Which ONE of the following statements regarding AD is INCORRECT?
It is graded in stages
It involves significant observable changes in the hippocampus compared with normal controls
Both encoding and retrieval of memories appears to be affected
Glucose uptake is impaired, especially in the temporo-occipital association cortex
Launguage impairment in AD is most often 'Wernicke'-type, i.e. fluent.
A is correct: The Braak and Braak staging schema is an example. B is correct: These are visible using radiographic imaging. C is correct: Especially in late stages, and can result in confabulation. D is incorrect: Glucose uptake is impaired in the temporo-parietal association cortex. E is correct: Speech is often "empty", dysnomia being a prominent feature.
The pathophysiology of AD includes the formation of 'neurofibrillary tangles'. Which one of the following is this NOT associated with?
Genetic predisposition, the profile of which appears to vary between the senile and non-senile onset forms of AD
Plaque formation between cells
Overproduction of β-amyloid protein
Collapsed microtubules and cell death
Apolipoprotein E4 and E2 have a recognised role in AD - E3 is the "normal" isoform. E1 is very rare in humans.